Antibody Developability Scientist

Company: AMERICAN VACUUM SOCIETY INC
Location: Livermore
Posted on: May 17, 2023

Job Description:

We are seeking a highly motivated and experienced Antibody Developability Scientist to join our team focused on developing next-generation antibody therapeutics with optimized developability and pharmacokinetics. You will work closely with other members of the research team to design and engineer antibody candidates with improved properties, using state-of-the-art techniques and technologies. The role includes opportunities to pursue self-driven research and development in infectious disease and countermeasure design for future pandemic preparedness as part of the Biosciences and Biotechnology Division. You will:

• Conduct assessments of antibody candidates and identify potential issues related to stability, aggregation, and other properties that may affect manufacturing and formulation.
• Proactively identify liabilities for antibody developability or pharmacokinetics and engineer mitigations using computational prediction tools, molecular biology, protein engineering, and other relevant techniques.
• Analyze and interpret data generated from traditional developability/PK studies and novel highthroughput proxy approaches to guide antibody design and optimization.
• Collaborate with our team of diverse expertise, including biochemists, infectious disease biologists, engineers, and computational biologists, to develop and optimize antibody screening and selection strategies.
• Contribute to and actively participate in the development of integrated research programs to meet sponsor needs in multiple national security focus areas. Interact with senior project staff and management to influence programmatic decisions.
• Interact with external collaborators and/or contract research organizations to explore and/or execute commercial complementation toward program goals.
• Develop new and innovative research approaches relevant to the needs of Laboratory programs and/or external funding agencies; write proposals, secure funding, and establish independent research projects.
• Prepare complex written analyses and verbal briefings and present research results at national and international conferences, technical meetings, periodic progress reports, and author scientific manuscripts.
• Perform other duties as assigned.
  • PhD in Biochemistry, Molecular Biology, or a field related to Antibody or Biopharmaceutical Engineering or the equivalent combination of education and relevant experience.
  • Demonstrated expertise in antibody engineering and protein design.
  • Advanced knowledge of high throughput developability and/or pharmacokinetics/pharmacodynamics, including assessment and mitigation strategies.
  • Ability to work collaboratively with researchers from diverse fields, including computational and experimental biologists, and provide scientific guidance, support, and leadership as needed.
  • Advanced written, verbal communication and interpersonal skills necessary to deliver presentations, prepare written reports and to interact with a diverse set of scientists, engineers, and other technical and administrative staff. Qualifications we desire :
    • Broad familiarity with sequence- and structure-based protein modeling tools.
    • Expertise in high throughput antibody production and screening platforms.
    • Familiarity with cutting edge protein display platforms (e.g., yeast, phage, etc.) for high throughput data generation or evaluation of developability, affinity, specificity, and stability.
    • Experience implementing and/or maintaining best practices for LIMS.
    • Strong leadership, communication, and project management skills.

Keywords: AMERICAN VACUUM SOCIETY INC, Livermore , Antibody Developability Scientist, Other , Livermore, California